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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE
All Species:
35.76
Human Site:
Y754
Identified Species:
87.41
UniProt:
Q07864
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07864
NP_006222.2
2286
261518
Y754
C
Q
R
E
N
S
F
Y
V
D
T
V
R
A
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543348
2273
260734
Y747
C
Q
R
E
N
S
F
Y
V
D
T
V
R
A
F
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVF7
2283
262009
Y754
C
Q
R
E
N
S
F
Y
V
D
T
V
R
A
F
Rat
Rattus norvegicus
NP_001100622
1515
174729
D123
E
S
G
V
F
R
S
D
I
P
C
R
F
R
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001233985
2277
260654
Y748
C
Q
R
E
N
S
F
Y
V
D
T
V
R
A
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001121995
2284
262166
Y753
C
Q
R
E
N
S
F
Y
V
D
T
V
R
A
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524462
2236
256683
Y752
C
Q
K
E
N
S
F
Y
V
D
T
V
R
A
F
Honey Bee
Apis mellifera
XP_393171
2183
252634
Y751
C
Q
K
E
N
S
F
Y
V
D
T
V
R
A
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002328167
2221
254636
Y727
C
M
R
E
N
S
F
Y
V
D
T
V
R
S
F
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P21951
2222
255653
Y770
C
Q
R
E
N
P
F
Y
V
D
T
V
K
S
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
90.7
N.A.
90.5
60.7
N.A.
N.A.
83.7
N.A.
80
N.A.
55.2
54.6
N.A.
N.A.
Protein Similarity:
100
N.A.
N.A.
94.6
N.A.
95
63.5
N.A.
N.A.
92
N.A.
90.2
N.A.
71.9
71.5
N.A.
N.A.
P-Site Identity:
100
N.A.
N.A.
100
N.A.
100
0
N.A.
N.A.
100
N.A.
100
N.A.
93.3
93.3
N.A.
N.A.
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
100
6.6
N.A.
N.A.
100
N.A.
100
N.A.
100
100
N.A.
N.A.
Percent
Protein Identity:
43.5
N.A.
N.A.
N.A.
40.5
N.A.
Protein Similarity:
62.7
N.A.
N.A.
N.A.
60.1
N.A.
P-Site Identity:
86.6
N.A.
N.A.
N.A.
80
N.A.
P-Site Similarity:
93.3
N.A.
N.A.
N.A.
93.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
70
0
% A
% Cys:
90
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
90
0
0
0
0
0
% D
% Glu:
10
0
0
90
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
10
0
90
0
0
0
0
0
10
0
90
% F
% Gly:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% I
% Lys:
0
0
20
0
0
0
0
0
0
0
0
0
10
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
90
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
0
% P
% Gln:
0
80
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
70
0
0
10
0
0
0
0
0
10
80
10
0
% R
% Ser:
0
10
0
0
0
80
10
0
0
0
0
0
0
20
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
90
0
0
0
0
% T
% Val:
0
0
0
10
0
0
0
0
90
0
0
90
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
90
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _